Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (4): 225-227.doi: 10.3969/j.issn.1004-616x.2003.04.012

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STUDIES OF EXPRESSION LEVELS OF p53，p21，p16，AND RBIN OVARIAN CARCINOMA AND BREAST CANCER

SHEN Zong-li,ZHU Yue-qing,WU Xiao-liu,et al   

  1. Cancer Institute of Jiangsu Province, Nanjing 210009,China
  • Received:2002-02-25 Revised:2003-05-13 Online:2003-10-30 Published:2003-10-30
  • Contact: SHEN Zong-li

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Abstract: Purpose: To study the clinical significance of expression levels of P53、Rb、P16 and P21 in cancer tissues. Methods: Flow cytometric analysis was used to detect abnormal expression of P53,Rb,P16,P21 in cancer tissues obtained from the 30 patients with ovarian carcinoma or breast cancer. Results: The expression levels and abnormal expression rates of P53、Rb、P16 and P21 in ovarian carcinoma were not differ from that in breast cancer.The abnormal expression rates of P53,P21,P16 and Rb in 30 cases were 40 ％, 66.7 ％ ,53.3 ％ and 53.3 ％ ,respectively. The rate of co-expression of two or more of them was 76.7 ％; 96.7 ％ (29/30) of tumors showed abnormalexpression of at least one item. Patients with abnormal expression of two items or more have clinical metastasis easily. Conclusion : Combination detection expression levels of P53,P21,P16 and Rb in cancer tissues , and comprehensive analysis of these parameters can be helpful to identify biological behavior of tumor and predict the prognosis .

Key words: tumor, P53, P21, P16, Rb